andriol side effects

The exact mechanism of the antitumor effect of the drug in Megeys endometrial carcinoma remains unknown. It is believed that the effect is due to the presence of antilyuteiniziruyuschego effect is realized through the pituitary gland. There is an indication of the local effect of megestrol obtained by direct administration of progestogen in the uterus.
The antitumor effect of the drug in breast cancer and the mechanism by which the drug is effective andriol side effects in anorexia and cachexia is also unknown. Weight gain when receiving megestrol acetate is associated with increased appetite and an increase in adipose tissue mass and the whole organism. Pharmacokinetics Plasma concentrations depend on the degree of inactivation of the drug in the blood and in the liver, to which may affect the mobility of the intestinal tract, intestinal microflora, the simultaneous use of antibiotics, body weight, diet, and liver function. Only about 5.8% of the administered dose into the body megestrol acetate metabolites accounted for. The main routes of drug release is the isolation of the human body by the kidneys (averaging approximately 66%) and intestine (average about 20% of the administered dose). That portion of the administered dose, which is not found in the urine and feces, can be released through the respiratory system and accumulate in the fatty tissue.

 

Indications for use:

– Palliative treatment of advanced breast cancer or endometrial cancer;
– treatment of anorexia or weight loss of malignancy or acquired immunodeficiency syndrome.

Contraindications:

 

  • hypersensitivity to megestrol acetate or any other substance included in the composition of the drug;
  • pregnancy in a diagnostic test;
  • Pregnancy and lactation
  • age of 18 years (effectiveness and safety have been established).Precautions Megeys should be used in patients with thrombophlebitis in history.

    Dosage and administration:

    Inside. To determine the effectiveness of the drug is necessary for at least two months of continuous treatment. Breast cancer: . 160 mg daily (in single or divided doses) Endometrial cancer: 80-320 mg per day (single dose or in divided doses). Anorexia andriol side effects and weight loss: once-daily dose is 400-800 mg. Elderly patients: No dosage adjustment is required.

    Side effect:

    Weight gain is a common effect when using the drug Megeys in patients with breast cancer or endometrial, and is the result of increased appetite. Thromboembolism. Reported cases of thromboembolism, including thrombophlebitis and pulmonary embolism. Other side effects. Nausea, vomiting, swelling and bleeding from the cavity uterus, not associated with menstruation, observed in approximately 1-2% of patients. It reported the presence in patients with dyspnea, pain, heart failure, hypertension, hot flushes, mood changes, Cushingoid features of the face, the temporary activation of the tumor (in the absence or presence of hypercalcemia), hyperglycemia, alopecia, carpal tunnel syndrome, diarrhea, lethargy, skin . rashes have been reported on the development of pathological conditions associated with impaired functioning of the pituitary-adrenal system: glucose intolerance, the occurrence of diabetes mellitus and exacerbation of existing diabetes with decreased glucose tolerance and Cushing’s syndrome. In rare cases, patients soon after the cessation of treatment MEGEYS showed clinical signs of adrenal insufficiency. It should be borne in mind the possibility of suppression of adrenal function in all patients taking the drug for a long time, and after drug withdrawal. In such cases, heavy doses of glucocorticoids as replacement therapy may be indicated.

    Overdose:

    In clinical studies, the drug was used in doses up to 1600 mg / day for 6 months or more. There were no acute toxic effects have been identified.
    In the case of overdose symptomatic treatment should andriol side effects be wearing character.

    special instructions

    Megeysom Treatment should be supervised by a professional with experience in the use of chemotherapy.
    Against Megeysom therapy and for at least 3 months after the need to use reliable methods of contraception.

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gerald andriole

Pieces gerald andriole of leaves of different shapes. Color grayish-green to yellowish-green, brownish-green and purple patches. Smell absent. Water extraction taste slightly bitter with a sensation of mucous membranes.
Infusion of mother and stepmother leaves has an expectorant, a weak anti-inflammatory action. The mucus, organic acids and saponins contribute to liquefaction of viscous discharge in the upper airway, improve sputum discharge. Due to the high content of mucus preparations mother and stepmother have an enveloping effect on the mucous membranes of the mouth, throat gerald andriole and larynx, protecting it from irritation.

Indications
Inflammatory airway disease (laryngitis, tracheitis, chronic bronchitis, pneumonia), accompanied by a cough with sputum difficult.

Contraindications
: Hypersensitivity to the drug, pregnancy, lactation, children under 12 years.

Dosing and Administration
Approximately gerald andriole 10 g (2 tablespoons) of a mother and stepmother, leaves are placed in an enamel bowl, pour 200 ml (1 cup) of boiling water, close lid and heated in a boiling water bath for 15 minutes, cooled at room temperature for 45 minutes, filtered, the remaining raw materials squeeze. The volume of the resulting infusion was adjusted with boiled water to 200 ml.
It is taken in the form of heat 2-3 tablespoons 2-3 times a day for 1 hour before meals.
Infusion is recommended Shake before use.

Side effects:
Allergic reactions are possible.

Composition
30 g, 35 g, 40 g, 45 g, 50 g, 60 g, 75 g, 100 g of crushed leaves in cardboard packs with an internal packet.
The full text of instructions is applied to the stack.

Storage conditions
In a dry place, protected from light; prepared infusion – in a cool place no more than 2 days.
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Pieces of leaves of different shapes. Color grayish-green to yellowish-green, brownish-green and purple patches. Smell absent. Water extraction taste slightly bitter with a sensation of mucous membranes.

Pharmacotherapeutic group:
expectorant buy andriol testocaps herbal.

Pharmacological action
Infusion of mother and stepmother leaves has an expectorant, a weak anti-inflammatory action. The mucus, organic acids and saponins contribute to liquefaction of viscous discharge in the upper airway, improve sputum discharge. Due to the high content of mucus preparations mother and stepmother have an enveloping effect on the mucous membranes of the mouth, throat and larynx, protecting it from irritation.

Indications
Inflammatory airway disease (laryngitis, tracheitis, chronic bronchitis, pneumonia), accompanied by a cough with sputum difficult.

Contraindications
: Hypersensitivity to the drug, pregnancy, lactation, children under 12 years.

Dosing and Administration
Approximately 10 g (2 tablespoons) of a mother and stepmother, leaves are placed in an enamel bowl, pour 200 ml (1 cup) of boiling water, close lid and heated in a boiling water bath for 15 minutes, cooled at room temperature for 45 minutes, filtered, buy andriol testocaps the remaining raw materials squeeze. The volume of the resulting infusion was adjusted with boiled water to 200 ml.
It is taken in the form of heat 2-3 tablespoons 2-3 times a day for 1 hour before meals.
Infusion is recommended Shake before use.

Side effects:
Allergic reactions are possible.

Composition
30 g, 35 g, 40 g, 45 g, 50 g, 60 g, 75 g, 100 g of crushed leaves in cardboard packs with an internal packet.
The full text of instructions is applied to the stack.

Storage conditions
In a dry place, buy andriol testocaps protected from light; prepared infusion – in a cool place no more than 2 days.
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andriol testosterone

It has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; enolovoy acid derivative. Meloxicam inhibits the synthesis of prostaglandins in inflammation to a greater extent than in the gastric mucosa and kidney, which is associated with relatively selective COX-2 inhibition.

In the appointment of high-dose, long-term use and individual andriol testosterone characteristics of the organism in relation to the selectivity of action of cyclooxygenase type 2 decreases.

Pharmacokinetics
The absorption from the gastrointestinal tract after oral administration – 89%. Food does not affect the absorption. The concentration in plasma is dose dependent.The average values of Cmax while taking 15 mg of the drug Mataram ® – 1.17 g / ml. The time to maximum concentration is between 4-6 hours. The equilibrium concentrations are reached after 3-5 days. Relationship to plasma proteins – 99%. It passes through the blood-tissue barrier, enters the synovial fluid. The volume of distribution is low, on average 11 l. Concentration in the synovial fluid – 50% of the plasma concentration. It is metabolized in the liver – to inactive metabolites.Displayed through the intestines and the kidneys (approximately equal proportions), in an unmodified form – 5% of the daily dose (in the intestines). The half – 20 hours. Plasma clearance – average of 8 ml / min (reduced in the elderly).

Indications
Rheumatoid arthritis; osteoarthritis; Ankylosing spondylitis (Bechterew’s disease) and other inflammatory and degenerative diseases of the joints, accompanied by pain syndrome.

CONTRAINDICATIONS
Hypersensitivity to any component of the drug, as well as non-steroidal anti-inflammatory drugs other groups;

A history of bronchial asthma, urticaria, or acute rhinitis, provoked by taking aspirin or other NSAIDs;

The aggravation of gastric ulcer and 12 duodenal ulcer;

Severe hepatic impairment;

Severe heart failure;

Chronic renal failure patients who are not undergoing hemodialysis;

Gastrointestinal, cerebrovascular bleeding or other.

Children’s age (12 years), pregnancy, lactation.

Precautions
The drug should be used with caution in elderly patients, in patients with erosive and ulcerative lesions of the gastrointestinal tract in history.

Pregnancy and lactation
Use during pregnancy is contraindicated.
In the period of lactation when using the drug should address the issue of termination of breastfeeding.

Dosing and Administration
Inside, during a meal, 1 time per day.

In rheumatoid arthritis and ankylosing spondylitis (ankylosing spondylitis), 15 mg / day, when a positive therapeutic effect, the dose can be reduced to 7.5 mg / day.

Osteoarthritis 7.5 mg / day, if necessary, increase the dose to 15 mg / day. The maximum daily dose of -15 mg.

The starting dose in patients with an increased risk of side effects is 7.5 mg / day. In patients with severe renal impairment on hemodialysis, the maximum daily dose of 7.5 mg. With low or moderate reduction of renal function (creatinine clearance for more than 25 ml / min), as well as in liver cirrhosis in stable clinical condition – dose adjustment is required.

Side effect
From the digestive system: more than 1% – indigestion, including nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea; 0.1-1% – transient increase in activity andriol testosterone of “liver” transaminases, hyperbilirubinemia, eructation, esophagitis, gastroduodenal ulcer, bleeding from the gastrointestinal tract (including hidden), stomatitis; less than 0.1% – gastrointestinal perforation, colitis, hepatitis, gastritis.

From the side of hematopoiesis: more than 1% – anemia; 0.1-1% – changes in blood counts, including leukopenia, tromotsitopeniya.

For the skin: more than 1% – itching, skin rash; 0.1-1% – urticaria; less than 0.1% -fotosensibilizatsiya, bullous rash, erythema multiforme, including Stevens-Johnson syndrome, toxic epidermal necrolysis.

The respiratory system: less than 0.1% – bronchospasm.

From the nervous system: more than 1% – dizziness, headache; 0.1-1% – vertigo, tinnitus, drowsiness; less than 0.1% – confusion, disorientation, emotional lability.

Since the cardiovascular system: more than 1% – peripheral edema; 0.1-1% -increase in blood pressure, palpitations, “tides” of blood to the skin.

From the urinary system: 0.1-1% – hypercreatininemia and / or an increase in urea in blood serum; less than 0.1% – acute renal failure; connection with the intake of meloxicam is not installed – interstitial nephritis, albuminuria, hematuria.

From the senses: less than 0.1% – conjunctivitis, visual disturbances, including blurred vision.

Allergic reaction: less than 0.1% – angioedema, anaphylactoid / anaphylactic reactions.

Overdose
Failure to comply with the recommended doses when taken orally, can cause drug overdose, manifested in increased side effects. Treatment: gastric lavage and symptomatic therapy. No specific antidotes and antagonists.

The interaction
when taken concomitantly with others. Nonsteroidal anti-inflammatory drugs increases the risk of ulcerative lesions of the gastrointestinal tract and gastrointestinal bleeding.

Meloxicam increases the concentration of lithium (Li +) in the plasma.

Reduces the effectiveness of intrauterine contraceptive, antihypertensive drugs.

Indirect anticoagulants, ticlopidine, heparin, thrombolytics increase risk of bleeding. Methotrexate amplifies mielodepressivnoe action without sharing recommended dose methotrexate 15mg a week.

Diuretics increase the risk of renal dysfunction.

Cyclosporin enhances nephrotoxicity.

Cholestyramine accelerates the elimination.

Myelotoxic drugs increase the expression gematotoksichnosti drug.

Cautions
If you have peptic ulcer or gastrointestinal bleeding, the development of side effects of the skin and mucous membranes, the drug should be discontinued.

In patients with decreased blood volume and reduced glomerular filtration (dehydration, congestive heart failure, liver cirrhosis, nephrotic syndrome, symptomatic renal disease, diuretics, andriol testosterone dehydration after major surgery) may cause clinically significant chronic renal failure, which is fully reversible after discontinuation of the drug (in these patients at the beginning of treatment should be monitored daily urine output and renal function). When persistent and substantial increase in transaminases and change others. Liver function parameters drug should be discontinued and conduct control tests.

In patients with an increased risk of side effects, treatment is initiated with a dose of 7.5 mg. In end-stage chronic renal failure patients on hemodialysis, the dose should not exceed 7.5 mg / day.

During the period of treatment must be careful (with the appearance of dizziness and drowsiness) when driving and other lesson. Potentially hazardous activities that require high concentration and psychomotor speed reactions. buy legal anabolic steroids online

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andriol cycle

The andriol cycle main active ingredient of the drug is madder dye dry extract obtained from the rhizomes and roots of madder dye – Rubia tinctorum L. and its Georgian variety Rubia tinctorum L. var.iberica Fisch. Ex DC. (R.iberica (Fisch ex DC) Koch Rubiaceae seed -.. Rubiaceae madder dye extract dry has diuretic and antispasmodic action, promotes loosening of urinary calculi containing calcium phosphate and magnesium and their excretion from the kidneys and urinary tract..

Indications
Tablets extract madder dye is used in adults with kidney disease to reduce spasms and facilitate the discharge of small stones and sand.

Contraindications
: Hypersensitivity to the drug, acute and chronic glomerulonephritis, severe renal insufficiency, peptic ulcer, galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Dosing and Administration
The drug is prescribed inside 1 tablet 3 times a day. If andriol cycle necessary, the dose may be increased to 2-3 tablets three times a day. Tablets before taking should be dissolved in 1/2 cup warm water.
The course of treatment 20-30 days. Repeat courses of treatment possible 4-6 weeks after consultation with the doctor.

Side effects
are possible allergic reactions. When using drugs madder dye urine turns a reddish color; with the appearance of intense staining of urine brownish-red color is necessary to reduce the dose or temporarily interrupt treatment.

Overdose
Overdose of drugs madder dye may cause the pain associated with andriol cycle the discharge of stones. ct fletcher steroids