The exact mechanism of the antitumor effect of the drug in Megeys endometrial carcinoma remains unknown. It is believed that the effect is due to the presence of antilyuteiniziruyuschego effect is realized through the pituitary gland. There is an indication of the local effect of megestrol obtained by direct administration of progestogen in the uterus.
The antitumor effect of the drug in breast cancer and the mechanism by which the drug is effective andriol side effects in anorexia and cachexia is also unknown. Weight gain when receiving megestrol acetate is associated with increased appetite and an increase in adipose tissue mass and the whole organism. Pharmacokinetics Plasma concentrations depend on the degree of inactivation of the drug in the blood and in the liver, to which may affect the mobility of the intestinal tract, intestinal microflora, the simultaneous use of antibiotics, body weight, diet, and liver function. Only about 5.8% of the administered dose into the body megestrol acetate metabolites accounted for. The main routes of drug release is the isolation of the human body by the kidneys (averaging approximately 66%) and intestine (average about 20% of the administered dose). That portion of the administered dose, which is not found in the urine and feces, can be released through the respiratory system and accumulate in the fatty tissue.
Indications for use:
– Palliative treatment of advanced breast cancer or endometrial cancer;
– treatment of anorexia or weight loss of malignancy or acquired immunodeficiency syndrome.
- hypersensitivity to megestrol acetate or any other substance included in the composition of the drug;
- pregnancy in a diagnostic test;
- Pregnancy and lactation
- age of 18 years (effectiveness and safety have been established).Precautions Megeys should be used in patients with thrombophlebitis in history.
Dosage and administration:
Inside. To determine the effectiveness of the drug is necessary for at least two months of continuous treatment. Breast cancer: . 160 mg daily (in single or divided doses) Endometrial cancer: 80-320 mg per day (single dose or in divided doses). Anorexia andriol side effects and weight loss: once-daily dose is 400-800 mg. Elderly patients: No dosage adjustment is required.
Weight gain is a common effect when using the drug Megeys in patients with breast cancer or endometrial, and is the result of increased appetite. Thromboembolism. Reported cases of thromboembolism, including thrombophlebitis and pulmonary embolism. Other side effects. Nausea, vomiting, swelling and bleeding from the cavity uterus, not associated with menstruation, observed in approximately 1-2% of patients. It reported the presence in patients with dyspnea, pain, heart failure, hypertension, hot flushes, mood changes, Cushingoid features of the face, the temporary activation of the tumor (in the absence or presence of hypercalcemia), hyperglycemia, alopecia, carpal tunnel syndrome, diarrhea, lethargy, skin . rashes have been reported on the development of pathological conditions associated with impaired functioning of the pituitary-adrenal system: glucose intolerance, the occurrence of diabetes mellitus and exacerbation of existing diabetes with decreased glucose tolerance and Cushing’s syndrome. In rare cases, patients soon after the cessation of treatment MEGEYS showed clinical signs of adrenal insufficiency. It should be borne in mind the possibility of suppression of adrenal function in all patients taking the drug for a long time, and after drug withdrawal. In such cases, heavy doses of glucocorticoids as replacement therapy may be indicated.
In clinical studies, the drug was used in doses up to 1600 mg / day for 6 months or more. There were no acute toxic effects have been identified.
In the case of overdose symptomatic treatment should andriol side effects be wearing character.
Megeysom Treatment should be supervised by a professional with experience in the use of chemotherapy.
Against Megeysom therapy and for at least 3 months after the need to use reliable methods of contraception.