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Antiparasitic agents. It violates the permeability to cations membranes of nerve cells of insects. Effective against scabies mites and maggots, larvae and mature specimens of head and pubic lice. Low-toxic to warm-blooded animals and humans, when applied to the skin at the recommended doses and concentrations has andriol bodybuilding not skin-resorptive, local irritant and sensitizing effect.

Indications
Scabies, head and pubic lice.

Contraindications
Individual intolerance, children up to 1 year.

Precautions
Pregnancy, lactation. During treatment for scabies should abandon breastfeeding.

Dosing and Administration: Scabies. The bottle, containing 24 ml of the drug (for ease of use on the bottle labels are applied), or 12 vials of 2 ml, calculated on a three-day course of treatment. Applied topically as a freshly prepared 0.4% aqueous emulsion 3.1 wherefore the vial (8 mL) or 4 ampoules of 2 ml was added to 100 ml of lukewarm water. The finished emulsion 1 time daily (at night) thoroughly rubbed into the skin of the upper extremities, trunk, and then the lower andriol bodybuilding extremities. Do not be processed skin of the face and neck, and scalp. At the end of treatment on the fourth day the patient should take a shower and spend the change underwear and bed linen. In the treatment of head and pubic lice is used externally in the form of a 0.2% freshly prepared aqueous emulsion. For emulsion 1/3 of the vial (8 mL) was added to 200 ml of lukewarm water. When used in the concentrate to obtain ampoules emulsion to 50 ml of water is added the contents of one vial (2 ml); with long, thick hair, and a high number of insects in 100 ml of water was added 4 ml of the preparation. The resulting aqueous emulsion liberally applied to wet hair or scalp hairy parts of the body (with pubic lice), gently rubbing the skin with a cotton swab. After 20 minutes of processing means rinsed with warm running water and soap (shampoo).

Side effects
In some cases, it may be a burning sensation at the site of drug, which takes place on their own after a few minutes. Allergic reactions.

Specific guidance
Avoid drug on eye mucosa, nasal and oral cavities and the mucous membrane of the external genitalia. In the case of getting the drug to the mucous membranes, they should be rinsed with running water. In the treatment of head lice in order to avoid getting the drug into the eyes of children from 1 year to put on the head of the protective visor or face scarf to throw, and the hands should be washed after handling.

Form release
Concentrate for emulsion preparation for external use 5% of 2 ml vials of neutral glass or polymer, 2 vials with a knife for opening packed in blisters of polymer and placed in a box made of cardboard packaged together with instructions for use; concentrate for the preparation of an emulsion for topical application of 5% in vials-droppers of dark andriol bodybuilding glass or plastic vials, rubber stoppers, dropper and screw-topped plastic screw cap, 24 ml, placed in a box made of cardboard together with instructions for use.

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Trimetazidine has antianginal, anti-hypoxic action. Directly affecting cardiomyocytes and neurons in the brain, improves their metabolism and function. Cytoprotective effect it is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, prevents a decrease in intracellular ATP and phosphocreatine. The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes intracellular concentration of potassium ions. Reduces buy andriol intracellular acidosis and phosphate, caused by myocardial ischemia and reperfusion. It prevents the damaging action of free radicals, preserves the integrity of cellular membranes, prevents activation of neutrophils in the ischemic area, increases the electric potential decreases the yield of the cells and creatine severity of ischemic myocardial injury.

When reducing the frequency of attacks of angina (nitrates reduced consumption), after 2 weeks of treatment, increases exercise capacity, reduced blood pressure drops. Improves hearing and vestibular trial results in patients decreases dizziness and tinnitus.

In vascular pathology eyes restores functional activity of the retina eyes.

Pharmacokinetics
After oral administration of trimetazidine is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability – 90%. The time to reach maximum plasma concentration – 6.5 hours. Easily penetrates the blood-tissue barriers. The half-life (T?) Is about 12 hours. Contact with blood plasma proteins – 16%. Report from the body by the kidneys (60% unchanged).

Indications
– Ischemic heart disease: prevention of angina attacks (in the complex therapy);
– chorioretinal vascular disorders;
– Vertigo of vascular origin;
– cochle-vestibular disorders ischemic nature (tinnitus, hearing impairment).

Contraindications
– Hypersensitivity to any component of the product;
– Renal insufficiency (creatinine clearance below 15 ml / min);
– Severe disturbances of liver function;
– Pregnancy;
– are breast-feeding period;
– age of 18 years (effectiveness and safety have been established) .

Dosage and administration
. Inside, during a meal in the morning and in the evening
recommended dosing regimen – 1 tablet 2 times a day. The course of treatment recommended by the doctor.

Side effects:
Allergic reactions (itchy skin). Rarely buy andriol from the gastrointestinal tract: gastralgia, nausea, vomiting; headache, feeling of palpitations.

Overdosing
Currently, the cases of overdose have been reported.

Interaction with other medicinal products
No information.

Cautions
Medarum MB is not intended for the relief of angina attacks and is not indicated for the initial course of therapy of unstable angina or myocardial infarction, as well as in preparation for hospitalization or in its first days.
The product has no effect on the ability to vehicle management and execution of works requiring high speed of mental buy andriol and physical reactions. Ou acheter des steroides, acheter steroide steroide anabolisant effet secondaire.

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Effective against the following microorganisms: Gram-positive Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae , Streptococcus A (Str pyogenes.), Streptococcus V (Str agalactiae.), Streptococcus andriol dosage viridans, Streptococcus bovis. Note : Staphylococcus spp, methicillin-resistant, resistant and. cephalosporins, including ceftriaxone. Most enterococci (e.g., Streptococcus faecalis) are also resistant to ceftriaxone. Gramotriiatelnye Aeromonas spp., Alcaligenes spp., Branhamella catarrhalis, Citrobacter spp., Enterobacter spp., (Some strains resistant), Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebssiella spp. (including Kl.pneumoniae), Moraxella spp., Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Plesiomonas shigelloides, Proteus mirabilis, Proteus vulgaris, Providencia spp., Pseudomonas aeruginosa ( some resistant strains), Salmonella spp., Vibrio spp., (including V.cholerae). Yersinia spp, (including Y. Enterocolitica).. Note : Many strains of these microorganisms, which in the presence of other antibiotics, such as penicillins, cephalosporins, aminoglycosides and first generations multiply resistant, susceptible to ceftriaxone. Treponema pallidum susceptible to ceftriaxone both in vitro, and in animal experiments. According to clinical data in primary and secondary syphilis say good efficacy of ceftriaxone. Anaerobic pathogens Bacleroides spp. (including some strains B.fragilis), Clostridium spp. (including C1. difficile), Fusobacterium spp. (except F.mostiferum, F.varium), Peptococcus spp, Peptostreptococcus spp.. Note : some of the many strains of Bacteroides spp.(e.g., B.fragilis), beta-lactamase-producing resistant to ceftriaxone. To determine the sensitivity of microorganisms necessary to use discs containing ceftriaxone, since it is shown that m vitro to classical cephalosporin certain strains can be resistant pathogens.

 

Pharmacokinetics
For parenteral administration of ceftriaxone well penetrates the tissues and body fluids.
In healthy adult subjects for ceftriaxone is characterized by long, about 8 hours, the half-life. The areas under the curve concentration – time in blood serum after intravenous and intramuscular administration of the same. This means that the bioavailability of ceftriaxone administered intramuscularly is 100%. When intravenous ceftriaxone diffuses rapidly into the interstitial fluid, where its bactericidal activity against susceptible thereto pathogens retains for 24 hours.
Tsefiriakson reversibly bound to albumin, and this binding is inversely proportional to the concentration of, for example, at a concentration in the blood serum of the drug is less than 100 mg / l ceftriaxone binding protein is 95%, and at a concentration of 300 mg / l – 85% only. Due to the lower content of albumin in the interstitial fluid ceftriaxone concentration therein is higher than in blood serum.
The half-life in healthy adult subjects is about 8 hours. Newborn to 8 days and older than 75 years, the average half-life of approximately twice Adult ceftriaxone 50-60% released in unaltered form in urine, and 40-50% – in unmodified form with bile. Under the influence of the intestinal flora ceftriaxone converted into an inactive metabolite. In newborns about 70% of the administered dose excreted by the kidneys. When kidney failure or liver disease in adults pharmacokinetics of ceftriaxone is almost unchanged, elimination half-life is lengthened slightly. If renal function is impaired, increased excretion in the bile, and if there is a liver disease, the enhanced release of ceftriaxone kidneys. Penetration into the cerebrospinal fluid : in infants and in children with inflammation of the meninges ceftriaxone penetrates into the cerebrospinal fluid, while in the case of bacterial meningitis in the middle 17% of the serum concentration of the drug diffuses into the cerebrospinal fluid, which is about 4 times greater than in aseptic meningitis. 24 hours after intravenous administration of ceftriaxone 50-100 mg / kg concentration in the cerebrospinal fluid of the body exceeds 1.4 mg / l. In adult patients with meningitis through 2-25 hours after administration of ceftriaxone 50 mg / kg body weight concentration ceftriaxone repeatedly exceeded the minimum dose of depressing, which is needed to suppress the pathogen most frequently cause meningitis.

Indications :
Infections caused by sensitive to ceftriaxone pathogens:
sepsis, meningitis, abdominal infections (peritonitis, inflammatory diseases of the gastrointestinal tract, biliary tract) infections of bones, joints, connective tissue, skin, infection in patients with lowered immunity, kidney and urinary tract infections, respiratory tract infections (including pneumonia), as well infection LOP organs, urogenital infections (including gonorrhea).
infections Prevention in the postoperative period.

Contraindications :
Hypersensitivity to andriol dosage cephalosporins and penicillin.
The first trimester of pregnancy. Precautions – hyperbilirubinemia in newborns, premature babies, kidney / liver failure, ulcerative colitis, enteritis or colitis associated s use of antibacterial drugs, pregnancy trimester 2-3, period lactation.

Dosage and administration :
The drug is administered intravenously and intramuscularly. For adults and children over 12 years of average daily dose is 1-2 g of ceftriaxone 1 per day (24 hours). In severe cases, or in cases of infections caused by moderately susceptible pathogens , a single daily dose may be increased to 4 years for newborns following scheme is recommended for single daily dosage: For infants (up to two weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg of body weight is not recommended to exceed due to immature newborn enzyme system). for infants and children up to 12 years of daily dose is 20-75 mg / kg body weight. in children weighing 50 kg and above should be followed dosage for adults. The dose of 50 mg / kg of body weight should be administered by intravenous infusion for at least 30 minutes. The duration of therapy – Depends on the disease. Meningitis In bacterial meningitis in infants and children initial dose of 100 mg / kg body weight once daily (maximum 4 g). For the treatment of gonorrhea, called as an image and not penicillinase forming strains, the recommended dose is 250 mg intramuscularly. Prevention in the pre- and postoperative period before infected or suspected infected surgical interventions for the prevention of postoperative infections, depending on the risk of infection, for 30-90 minutes prior to surgery is recommended single injection of ceftriaxone in a dose of 1-2 g Insufficient renal and hepatic function in patients with impaired renal function, under normal liver function, reduce the dose of ceftriaxone is not necessary. Only with kidney failure in preterminal stage (creatinine clearance below 10 ml / min), it is necessary that the daily dose of ceftriaxone should not exceed 2 years in patients with impaired liver function, while maintaining renal function, reduce the dose of ceftriaxone is also not necessary. In the case of simultaneous the presence of severe liver disease and kidney failure in the serum concentration of ceftriaxone should be regularly monitored. In patients undergoing hemodialysis, the dose after this procedure, there is no need to change. Intramuscular administration For intramuscular administration of 1 g of the drug should be diluted in 3.5 mL of 1% lidocaine and enter deeply into the gluteal muscle, it is advisable to enter no more than 1 g preparation of one buttock. Lidocaine solution should never be administered intravenously! Intravenous administration For intravenous injection of 1 g of the drug must dissolve in 10 ml of sterile distilled water and administered by slow intravenous injection over 2-4 minutes. Intravenous infusion duration of an intravenous infusion for at least 30 minutes. For intravenous infusion 2 g of the powder should be diluted with approximately 40 ml of solution free of calcium, such as 0.9% sodium chloride solution, 5% dextrose solution, 10% dextrose, 5% fructose solution.

 

Side effects : Allergic reactions : rash, chills or fever, rash, pruritus, rarely – bronchospasm, eosinophilia, erythema polymorph, exudative (including Stevens-Johnson syndrome), serum sickness, angioedema, anaphylactic shock. Digestive system : nausea, vomiting, diarrhea or constipation, bloating, abdominal pain, taste disturbance, stomatitis, glossitis, pseudomembranous enterocolitis, liver dysfunction (increased activity of “liver” transaminases, less often – ALP or bilirubin, cholestatic jaundice), dysbiosis. From the of hematopoiesis : leukopenia, neutropenia, granulocytopenia, lymphopenia, thrombocytosis, thrombocytopenia, hemolytic anemia, anticoagulation, lowering the concentration of plasma clotting factors (I, VII, IX, X), prolonged prothrombin time. From the urinary system : azotemia, elevated levels of urea blood hypercreatininemia, glycosuria, cylindruria, hematuria, oliguria, anuria. Local reactions : phlebitis, pain along the vein, pain and infiltration in the ground / m introduction. Other : headache, dizziness, nosebleeds, candidiasis, superinfection.

Drug Interactions : Combination therapy between ceftriaxone and aminoglycosides on effect on many Gram-negative bacteria is synergism. Although predict enhancement of the effect of such combinations can not be, in cases of severe and life-threatening infections (eg, caused by Pseudomonas aeruginosa) justified their co-administration. Due to physical incompatibility between ceftriaxone and the aminoglycoside should be prescribed them in the recommended doses separately! Incompatible with ethanol. NSAIDs and et al. platelet aggregation inhibitors increase the chance of bleeding. in an application with the “loop” diuretics, etc. the risk of increased nephrotoxic drugs nephrotoxic effect. Pharmaceutical incompatible with solutions containing other. antibiotics. You can not mix in the same infusion vial or a syringe with other antibiotic (chemical incompatibility).

Overdosing
Excessively high concentrations of ceftriaxone plasma can not be reduced by hemodialysis or peritoneal dialysis. For treatment of overdose symptomatic measures are recommended.

Special instructions :
. When simultaneous severe renal and hepatic impairment should be regular monitoring of the concentration of drug in plasma
in patients on hemodialysis, you must monitor the concentration of ceftriaxone in plasma, because have its elimination rate may be reduced.
In the long-term treatment should be regularly monitored picture peripheral blood, indicators of the functional state of the liver and kidneys.
In rare cases, ultrasound gallbladder marked darkening, which disappear after canceling (Lager if this phenomenon is accompanied by pain in the right upper quadrant, recommends continuation of the appointment of an antibiotic and conduct symptomatic treatment).
During treatment contraindicated use of ethanol – can disulfiramopodobnye effects (redness of the face, a spasm in the stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).
in spite of the detailed medical history, that is the rule for other cephalosporin antibiotics, we can not exclude the possibility of an anaphylactic shock, which requires immediate treatment – first intravenous epinephrine, followed by glucocorticoids.
Studies in vitro have shown that, like andriol dosage other cephalosporin antibiotics ceftriaxone is able to displace bilirubin bound to albumin serum. Therefore, in infants with hyperbilirubinemia and especially in premature infants, the use of ceftriaxone requires even greater care.
Freshly prepared solutions of ceftriaxone is physically and chemically stable for 6 hours at room temperature.
In the appointment during lactation should be abolished breastfeeding.
Elderly or debilitated patients may require the appointment of vitamin K. Comprar esteroides espana, winstrol oral comprar comprar esteroides contrareembolso!

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Megadin a combination of vitamins and minerals.
Vitamin A (retinol) is a fat-soluble vitamin. When vitamin A deficiency develop Keratomalacia, xerophthalmia and night blindness. Vitamin E, thanks to its antioxidant action, protecting the cells from damage by free radicals. Vitamin C is involved in the regeneration of tissue, collagen formation. Complex B vitamins involved in the conversion of carbohydrates, protein and fats. Vitamin D ensures the normal development of bones and teeth, regulates calcium laisa andriol utilization in the body. Nicotinamide and Biotin involved in various biochemical reactions. Phosphate and calcium needed for bone mineralization; Iron and copper are involved in hematopoiesis, zinc, molybdenum, magnesium and manganese are essential elements.

Indications for use
during convalescence treatment of vitamin and mineral deficiency after long illnesses, in pre- and postoperative period, malabsorption due to disease of the gastrointestinal tract.

Contraindications
Hypervitaminosis A or the D, hypercalcemia or hypercalciuria, increased sensitivity to the drug, pregnancy.

Dosing and Administration
In one tablet a day during breakfast.

Side effects:
Allergic reactions are possible. In high doses and long-term use possible reactions such as allergic rashes, mucosal ulceration.

Overdose
should be emphasized that Megadin, at recommended doses in the insert of overdose or poisoning phenomena do not cause. Since Megadin Pronatal contains fat-soluble vitamins A and D, signs of acute or chronic overdose may develop after a single dose of high-dose or long-term use.
Signs of overdose of vitamin A include headache, dizziness, irritability, confusion, loss of appetite, vomiting, diarrhea, dry skin, and visual disturbances.
The laisa andriol main symptoms of an overdose of vitamin D- nausea, vomiting, constipation, headache, dizziness, drowsiness, calcium deposits in the internal organs (kidneys).
in case of overdose it is recommended to cancel the drug and conduct symptomatic treatment.

Interaction with other medicines
Do not use simultaneously with tetracyclines due to the potential adverse interaction.
If the reception is shown in the application of tetracycline Megadina, the interval between administration of these two drugs should be approximately two hours.

Cautions
Megadin should be used at recommended doses. In high doses can cause hypervitaminosis Megadin.
Megadin can not be used concurrently with other medicinal products containing vitamins and minerals laisa andriol without a prescription. anabolic steroids online lipolaser machine where can i buy anabolic steroids online

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The exact mechanism of the antitumor effect of the drug in Megeys endometrial carcinoma remains unknown. It is believed that the effect is due to the presence of antilyuteiniziruyuschego effect is realized through the pituitary gland. There is an indication of the local effect of megestrol obtained by direct administration of progestogen in the uterus.
The antitumor effect of the drug in breast cancer and the mechanism by which the drug is effective andriol side effects in anorexia and cachexia is also unknown. Weight gain when receiving megestrol acetate is associated with increased appetite and an increase in adipose tissue mass and the whole organism. Pharmacokinetics Plasma concentrations depend on the degree of inactivation of the drug in the blood and in the liver, to which may affect the mobility of the intestinal tract, intestinal microflora, the simultaneous use of antibiotics, body weight, diet, and liver function. Only about 5.8% of the administered dose into the body megestrol acetate metabolites accounted for. The main routes of drug release is the isolation of the human body by the kidneys (averaging approximately 66%) and intestine (average about 20% of the administered dose). That portion of the administered dose, which is not found in the urine and feces, can be released through the respiratory system and accumulate in the fatty tissue.

 

Indications for use:

– Palliative treatment of advanced breast cancer or endometrial cancer;
– treatment of anorexia or weight loss of malignancy or acquired immunodeficiency syndrome.

Contraindications:

 

  • hypersensitivity to megestrol acetate or any other substance included in the composition of the drug;
  • pregnancy in a diagnostic test;
  • Pregnancy and lactation
  • age of 18 years (effectiveness and safety have been established).Precautions Megeys should be used in patients with thrombophlebitis in history.

    Dosage and administration:

    Inside. To determine the effectiveness of the drug is necessary for at least two months of continuous treatment. Breast cancer: . 160 mg daily (in single or divided doses) Endometrial cancer: 80-320 mg per day (single dose or in divided doses). Anorexia andriol side effects and weight loss: once-daily dose is 400-800 mg. Elderly patients: No dosage adjustment is required.

    Side effect:

    Weight gain is a common effect when using the drug Megeys in patients with breast cancer or endometrial, and is the result of increased appetite. Thromboembolism. Reported cases of thromboembolism, including thrombophlebitis and pulmonary embolism. Other side effects. Nausea, vomiting, swelling and bleeding from the cavity uterus, not associated with menstruation, observed in approximately 1-2% of patients. It reported the presence in patients with dyspnea, pain, heart failure, hypertension, hot flushes, mood changes, Cushingoid features of the face, the temporary activation of the tumor (in the absence or presence of hypercalcemia), hyperglycemia, alopecia, carpal tunnel syndrome, diarrhea, lethargy, skin . rashes have been reported on the development of pathological conditions associated with impaired functioning of the pituitary-adrenal system: glucose intolerance, the occurrence of diabetes mellitus and exacerbation of existing diabetes with decreased glucose tolerance and Cushing’s syndrome. In rare cases, patients soon after the cessation of treatment MEGEYS showed clinical signs of adrenal insufficiency. It should be borne in mind the possibility of suppression of adrenal function in all patients taking the drug for a long time, and after drug withdrawal. In such cases, heavy doses of glucocorticoids as replacement therapy may be indicated.

    Overdose:

    In clinical studies, the drug was used in doses up to 1600 mg / day for 6 months or more. There were no acute toxic effects have been identified.
    In the case of overdose symptomatic treatment should andriol side effects be wearing character.

    special instructions

    Megeysom Treatment should be supervised by a professional with experience in the use of chemotherapy.
    Against Megeysom therapy and for at least 3 months after the need to use reliable methods of contraception.

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