Trimetazidine has antianginal, anti-hypoxic action. Directly affecting cardiomyocytes and neurons in the brain, improves their metabolism and function. Cytoprotective effect it is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, prevents a decrease in intracellular ATP and phosphocreatine. The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes intracellular concentration of potassium ions. Reduces buy andriol intracellular acidosis and phosphate, caused by myocardial ischemia and reperfusion. It prevents the damaging action of free radicals, preserves the integrity of cellular membranes, prevents activation of neutrophils in the ischemic area, increases the electric potential decreases the yield of the cells and creatine severity of ischemic myocardial injury.
When reducing the frequency of attacks of angina (nitrates reduced consumption), after 2 weeks of treatment, increases exercise capacity, reduced blood pressure drops. Improves hearing and vestibular trial results in patients decreases dizziness and tinnitus.
In vascular pathology eyes restores functional activity of the retina eyes.
After oral administration of trimetazidine is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability – 90%. The time to reach maximum plasma concentration – 6.5 hours. Easily penetrates the blood-tissue barriers. The half-life (T?) Is about 12 hours. Contact with blood plasma proteins – 16%. Report from the body by the kidneys (60% unchanged).
– Ischemic heart disease: prevention of angina attacks (in the complex therapy);
– chorioretinal vascular disorders;
– Vertigo of vascular origin;
– cochle-vestibular disorders ischemic nature (tinnitus, hearing impairment).
– Hypersensitivity to any component of the product;
– Renal insufficiency (creatinine clearance below 15 ml / min);
– Severe disturbances of liver function;
– are breast-feeding period;
– age of 18 years (effectiveness and safety have been established) .
Dosage and administration
. Inside, during a meal in the morning and in the evening
recommended dosing regimen – 1 tablet 2 times a day. The course of treatment recommended by the doctor.
Allergic reactions (itchy skin). Rarely buy andriol from the gastrointestinal tract: gastralgia, nausea, vomiting; headache, feeling of palpitations.
Currently, the cases of overdose have been reported.
Interaction with other medicinal products
Medarum MB is not intended for the relief of angina attacks and is not indicated for the initial course of therapy of unstable angina or myocardial infarction, as well as in preparation for hospitalization or in its first days.
The product has no effect on the ability to vehicle management and execution of works requiring high speed of mental buy andriol and physical reactions. Ou acheter des steroides, steroide anabolisant effet secondaire.